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KMT2A-rearranged acute lymphoblastic leukemia

KMT2A-rearranged acute lymphoblastic leukemia is a genomic subtype of ALL associated with aggressive disease behavior and early relapse.

Also called: KMT2A-rearranged disease

This leukemia subtype is defined by rearrangement of the KMT2A gene. It appears among genetic features used to describe risk in childhood acute lymphoblastic leukemia. Pediatric reports associate the rearranged subtype with an aggressive course and early relapse, distinguishing it from ALL defined only by lineage.

Card id: kmt2a-rearranged-disease

Sources

  • Updates in KMT2A Gene Rearrangement in Pediatric Acute Lymphoblastic Leukemia, Li S et al., Frontiers in Oncology, 2023, https://pmc.ncbi.nlm.nih.gov/articles/PMC10045821/

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