Neuron-specific enolase

Serum neuron-specific enolase is one of several markers measured in neuroblastoma. A critical appraisal of the literature found no definitive evidence for using it to diagnose or monitor the disease. Its main value is prognostic, where it may help estimate the risk of death, mainly in advanced stages. False-positive results are a notable problem because hemolysis and inflammation can raise measured levels, so results need cautious interpretation.