Criteria

Laboratory tumor lysis syndrome criteria

The Cairo–Bishop 2004 rule identifies laboratory tumor lysis syndrome when at least two metabolic abnormalities occur within the specified treatment-related window.

Also called: Laboratory TLS

Criteria not met

2 laboratory

Laboratory abnormalities

Uric acid ≥8.0 mg/dL or ≥25% above baseline
Potassium ≥6.0 mmol/L or ≥25% above baseline
Phosphate ≥6.5 mg/dL in children or ≥25% above baseline
Calcium ≤7.0 mg/dL or ≥25% below baseline

Educational use only. Guideline: Cairo–Bishop 2004; pediatric phosphate threshold. Source: Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. British Journal of Haematology, 2004, https://pubmed.ncbi.nlm.nih.gov/15384972/; Oncologic emergencies: recognition and initial management. American Family Physician, 2018, https://www.aafp.org/afp/2018/0601/p741.

The rule counts abnormalities measured together during one 24-hour period, within 3 days before through 7 days after treatment begins. For children, its phosphate threshold is higher than the adult threshold. It gives students a structured way to distinguish a pattern of laboratory tumor lysis from an isolated abnormal result.

Learn it in

Oncologic Emergencies in ChildrenPediatrics