Staging
International Neuroblastoma Risk Group Staging System
The 2009 INRG staging system assigns neuroblastoma stage before treatment using imaging-based risk factors and whether disease is localized or metastatic.
Also called: INRGSS
Stages
- L1
Localized, no image-defined risk factors
Locoregional tumor without any image-defined risk factor.
- L2
Localized, with image-defined risk factors
Locoregional tumor with at least one image-defined risk factor.
- M
Metastatic
Metastatic disease that does not meet the MS definition.
- MS
Special metastatic category
Metastases limited to skin, liver and/or bone marrow in a child younger than 18 months.
Judged onPretreatment imaging, image-defined risk factors and metastatic distribution
INRGSS was created for staging before treatment, unlike the postsurgical INSS system. It separates localized tumors according to the presence of image-defined risk factors, then distinguishes metastatic disease from a defined infant and toddler metastatic pattern. The pretreatment stage gives a common way to describe neuroblastoma extent across risk assessment and clinical studies.
Learn it in
- NeuroblastomaPediatrics